Mechanisms of guanylin action on water and ion absorption at different regions
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چکیده
1 2 Mechanisms of guanylin action on water and ion absorption at different regions 3 of seawater eel intestine 4 5 6 Masaaki Ando, Marty K. S. Wong and Yoshio Takei 7 8 Laboratory of Physiology, Department of Marine Bioscience, Atmosphere and Ocean 9 Research Institute, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8564, 10 Japan 11 12 13 Running title: Guanylin and intestinal absorption in fish 14 15 16 To whom correspondence should be addressed: 17 Dr. Yoshio Takei 18 Tel.: +81-4-7136-6200 19 Fax: +81-4-7136-6201 20 E-mail address: [email protected] 21 22 23 24 Abbreviations 25 AE, anion exchanger; ANP, atrial natriuretic peptide; AQP, aquaporin, CFTR, cystic fibrosis 26 transmembrane conductance regulator; DIDS, 4,4’-diisothiocyano-2,2’-disulfonic acid; DPC, 27 diphenylamine2-carboxylic acid, GC-C, guanylyl cyclase-C; GN, guanylin; HCTZ, 28 hydrochlorothiazide; Isc, short-circuit current; MI, middle intestine; NCC, Na-Cl 29 cotransporter; NKA, Na/K-ATPase; NKC system, Na-K-Cl transport system; NKCC, 30 Na-K-2Cl cotransporter; NPPB, 5-nitro-2-(3-phenylpropylamino) benzoic acid; PD, 31 transepithelial potential difference; PI, posterior intestine; RGN, renoguanylin; Rt, tissue 32 resistance; SLC, Solute Carrier; UGN, uroguanylin 33 34 Articles in PresS. Am J Physiol Regul Integr Comp Physiol (July 2, 2014). doi:10.1152/ajpregu.00543.2013
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Mechanisms of guanylin action on water and ion absorption at different regions of seawater eel intestine.
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